Natural product chemistry and synthesis

BIOGENIC ZNO NANOPARTICLES: STRUCTURAL CHARACTERIZATION AND BIOACTIVITY EVALUATION

Author(s):

Abhimanyu Parasram Pawar, Kishor Sudhir Naktode, Arvind Janardhan Mungole, Srinivas Angac

Field: Natural product chemistry and synthesis
Type: Research paper
Issue: 2025 Volume 20, no.1
Pages: 51-61

Keywords: green synthesis, ZnO nanoparticle, EDX, FT-IR, SEM, antibacterial activity, antioxidant activity.
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https://doi.org/10.19261/cjm.2025.1308

Abstract (PDF)

Graphycal Abstract: Zinc oxide nanoparticles (ZnO NPs) were synthesized using Nicotiana plumbaginifolia plant extract through a green approach. XRD, FTIR, and EDX confirmed their hexagonal wurtzite structure and high purity. SEM and TEM showed spherical ZnO NPs (16–24 nm), with a band gap of 3.33 eV. FTIR spectra displayed a peak at 480 cm⁻¹, confirming Zn–O bond formation. The ZnO NPs exhibited strong antibacterial activity against P. aeruginosa, E. coli,
K. pneumoniae, and S. aureus at 100 µL using the well diffusion method. They also showed excellent antioxidant potential, scavenging DPPH radicals with 75.59% inhibition at 250 μg/mL. This eco-friendly synthesis method offers a sustainable approach for ZnO NP production, highlighting their potential for biomedical and pharmaceutical applications.

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MOLECULAR DOCKING STUDY OF SOME ACTIVE PRINCIPLES FROM SILYBUM MARIANUM, CHELIDONIUM MAJUS, GINKGO BILOBA, GELSEMIUM SEMPERVIRENS, ARTEMISIA ANNUA, AND TARAXACUM OFFICINALE

Author(s):

Daniel Cord, Mirela Claudia Rimbu, Cristiana Tanase, Cristina Tablet, Gheorghe Duca

Field: Natural product chemistry and synthesis
Type: Short communication
Issue: 2025 Volume 20, no.1
Pages: 100-105

Keywords: natural compound, molecular docking, apelin receptor, β2-adrenoceptor, A2B adenosine receptor.
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https://doi.org/10.19261/cjm.2025.1337

Abstract (PDF)

Supplementary Material (PDF)

Graphycal Abstract: Interactions between various natural compounds and three selected G protein coupled receptors were investigated through molecular docking. The strongest binding affinities were identified highlighting potential modulators for these receptors.

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FATTY ACID ETHYL ESTERS AS BIODIESEL FUEL: PRODUCT QUALITY AND EFFICIENCY OF VARIOUS PURIFICATION TECHNIQUES

Author(s):

Lyubov Patrylak, Serhiy Konovalov, Stepan Zubenko, Angela Yakovenko, David Davitadze, Olexandra Pertko

Field: Natural product chemistry and synthesis
Type: Research paper
Issue: 2024 Volume 19, no.2
Pages: 63-73

Keywords: fatty acid ethyl ester, purification, sorbent, distillation and ion exchange resin.
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https://doi.org/10.19261/cjm.2024.1236

Abstract (PDF)

Supplementary Material (PDF)

Graphycal Abstract: The efficiency of removing glycerol, soaps, and unconverted acylglycerols from crude fatty acid ethyl esters by different techniques was evaluated. The proposed purification scheme allows for obtaining a product that meets the quality indicators of EN 14214 and can be used as a biodiesel fuel component.

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OPTIMIZATION OF ULTRASOUND-ASSISTED EXTRACTION OF ANTIOXIDANT PHENOLICS FROM ALGERIAN TRIFOLIUM TOMENTOSUM L. USING RESPONSE SURFACE METHODOLOGY

Author(s):

Radia Hannache, Radia Ayad, Nassima Boutaoui, Hayat Bourekoua, Mostefa Lefahal, El Hani Makhloufi, Nabila Souilah, Salah Akkal, Kamel Medjroubi

Field: Natural product chemistry and synthesis
Type: Research paper
Issue: 2024 Volume 19, no.2
Pages: 52-62

Keywords: Trifolium tomentosum L., antioxidant phenolics, green process, ultrasonic, response surface methodology.
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https://doi.org/10.19261/cjm.2024.1221

Abstract (PDF)
Graphycal Abstract: The current study aims to maximize the recovery of antioxidant phenolics from Algerian Trifolium tomentosum L. using an innovative green process: ultrasonic assisted extraction (UAE). Using response surface methodology (RSM), the optimal UAE parameters for maximum responses (total phenolic content, total flavonoid content, and total antioxidant capacity) were 70% ethanol concentration, 30.45 minutes of extraction time, and 75°C extraction temperature.

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CHEMICAL COMPOSITION AND ANTIMICROBIAL ACTIVITY OF MARRUBIUM DESERTI DE NOÉ ESSENTIAL OIL

Author(s):

Amina Mazeri, Achraf Khaldi, Mehdi Kheira, Adel Benarfa, Hadjer Saber

Field: Natural product chemistry and synthesis
Type: Research paper
Issue: 2024 Volume 19, no.2
Pages: 45-51

Keywords: chemical composition, essential oil, Marrubium deserti de Noé, antibacterial, antifungal.
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https://doi.org/10.19261/cjm.2024.1219

Abstract (PDF)

Supplementary Material (PDF)

Graphycal Abstract: The essential oil of Marrubium deserti from Bechar (Algeria) was investigated to determine its chemical composition, physico-chemical characteristics,the antibacterial and antifungal activities. The findings showed that α-phellandrene (25.05%), β-pinene (14.05%), and α-pinene (12.83%) were the major compounds of this oil. Moreover, it was displayed that the studied essential oil has good antibacterial power as well as a strong inhibitory effect on spore sporulation, germination, and pathogen fungus development.

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SYNTHESIS OF CYCLE B FUNCTIONALIZED DERIVATIVES OF (+)-LARIXOL

Author(s):

Alexandru Ciocarlan, Lidia Lungu, Svetlana Blaja, Sergiu Shova, Aculina Aricu

Field: Natural product chemistry and synthesis
Type: Research paper
Issue: 2024 Volume 19, no.1
Pages: 69-75

Keywords: (+)-larixol, enolacetylation, dye-sensitized photooxidation, reduction, X-ray analysis.
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https://doi.org/10.19261/cjm.2024.1156

Abstract (PDF)
Supplementary Material (PDF)
Graphical Abstract: The main purpose of this research was the synthesis of highly functionalized derivatives of (+)-larixol by combination of classical and nonconventional method, like dye-sensitized photooxidation with preservation of outside chain. As a result, a series of four new cycle B derivatives of (+)-larixol were obtained. The structure of all synthesized compounds was fully confirmed by spectral method (IR, ¹H and ¹³C NMR) and for compound containing endoperoxide functional group, additionally by single crystal X-ray diffraction analysis.

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CHEMICAL COMPOSITION AND ANTIOXIDANT ACTIVITY OF LIPIDS FROM FICUS CARICA L. FRUITS

Author(s):

Hadjira Naoui, Mohamed Benalia, Soumaya Hachani, Amar Djeridane, Ziyad Ben Ahmed, Veronique Seidel, Mohamed Yousfi

Field: Natural product chemistry and synthesis
Type: Research paper
Issue: 2023 Volume 18, no.1
Pages: 92-101

Keywords: oil extract, fatty acid, tocopherol, sterol, antioxidant activity.
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https://doi.org/10.19261/cjm.2022.1029

Abstract (PDF)
Graphical Abstract: Samples of oils from seven types of Ficus carica L. fruits from Algeria were investigatedwith the aim to assess the chemical characteristics, quantifying sterols and tocopherols, and to analyse the fatty acids profiles using gas chromatography, and evaluation of antioxidant activity by 1,1-diphenyl-2-picrylhydrazyl method and total antioxidant activity using phosphomolybdenum methods. The results showed that the major unsaturated fatty acids of different lipid classes were linoleic (11.70-34.74%) and linolenic (1.15-35.27%), the main saturated fatty acids was palmitic. Aditionally, it was demonstrated for the first time that the studied figs oils possessed good antioxidant activity which may be associated with their alleged health benefits.

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SYNTHESIS AND EVALUATION OF ANTIMICROBIAL ACTIVITY OF TETRANORLABDANE COMPOUNDS BEARING 1,3,4-THIADIAZOLE UNITS

Author(s):

Svetlana Blaja, Lidia Lungu, Alexandru Ciocarlan, Nicoleta Vornicu, Aculina Aricu

Field: Natural product chemistry and synthesis
Type: Research paper
Issue: 2023 Volume 18, no.1
Pages: 86-91

Keywords: (+)-sclareolide, tetranorlabdane compound, 1,3,4-thiadiazole, thiosemicarbazone, antimicrobial activity.
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https://doi.org/10.19261/cjm.2022.1026

Abstract (PDF)
Graphical Abstract: The study describes the synthesis of novel tetranorlabdane compounds bearing 1,3,4-thiadiazole units and intermediary tetranorlabdane compounds with thiosemicarbazone fragment. The structures of the synthesized compounds were confirmed using IR and ¹H, ¹³C, and ¹⁵N NMR spectroscopy. The in vitro antifungal and antibacterial activities of the tetranorlabdane compounds with thiosemicarbazone and 1,3,4-thiadiazole units have been evaluated. One of the tested compounds has an excellent activity against five strains of fungi and two species of bacteria at minimum inhibitory concentration values of 0.125 and 2.5 µg/mL, respectively.

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FROM (-)-SCLAREOL TO NORLABDANE HETEROCYCLIC HYBRID COMPOUNDS

Author(s):

Alexandru Ciocarlan

Field: Natural product chemistry and synthesis
Type: Review
Issue: 2022 Volume 17, no.2
Pages: 19-34

Keywords: (-)-sclareol, norlabdane-heterocyclic compound, antimicrobial activity, biological activity.
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https://doi.org/10.19261/cjm.2022.958

Abstract (PDF)

Graphical Abstract: This review relates to chemistry of the well-known biologically active natural labdane diterpenoid (-)-sclareol easily available from Clary sage (Salvia sclarea L.). It is mainly used in industry, especially for synthesis of fragrance compounds and natural analogs. The paper covers achievements on the synthesis, structure determination and biological activity of molecular hybrid compounds bearing hydrazide and thiosemicarbazone fragments or diazine, 1,2,4-triazole, carbazole, 1,3-thiazole, 1,3,4-oxadiazole, 1,3,4-thiadiazole units prepared based on it.

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ISOMERIZATION OF LIMONENE ON ZEOLITE-CONTAINING CATALYSTS BASED ON KAOLIN

Author(s):

Lyubov Patrylak, Stepan Zubenko, Serhyi Konovalov, Anzhela Yakovenko, Volodymyr Povazhnyi, Oleksandra Pertko, Yulia Voloshyna, Oleksandr Melnychuk, Mykhailo Filonenko

Field: Natural product chemistry and synthesis
Type: Research paper
Issue: 2022 Volume 17, no.2
Pages: 84-93

Keywords: kaolin, zeolite, limonene isomerization, terpinolene yield.
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https://doi.org/10.19261/cjm.2022.980

Abstract (PDF)
Graphical Abstract: The aim of the work was to study the isomerization of limonene on zeolite-containing biporous acid catalysts based on kaolin (from Ukraine). Results of this study show that at 160°C, the maximum isomer yield was 60–65% with an 80–90% conversion. The studied samples do not have a significant accumulation of carbonaceous deposits because limonene has high solubility, which helps to remove intermediate products of transformation from the surface of the samples.

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