Chemistry Journal of Moldova

SYNTHESIS OF CYCLE B FUNCTIONALIZED DERIVATIVES OF (+)-LARIXOL

Author(s):

Alexandru Ciocarlan, Lidia Lungu, Svetlana Blaja, Sergiu Shova, Aculina Aricu


Field: Natural product chemistry and synthesis
Type: Research paper
Issue: 2024 Volume 19, no.1
Pages: 69-75
Keywords:

(+)-larixol, enolacetylation, dye-sensitized photooxidation, reduction, X-ray analysis.


Full Text (PDF): Download
 
https://doi.org/10.19261/cjm.2024.1156

Abstract (PDF)
Supplementary Material (PDF)
Graphical Abstract: The main purpose of this research was the synthesis of highly functionalized derivatives of (+)-larixol by combination of classical and nonconventional method, like dye-sensitized photooxidation with preservation of outside chain. As a result, a series of four new cycle B derivatives of (+)-larixol were obtained. The structure of all synthesized compounds was fully confirmed by spectral method (IR, 1H and 13C NMR) and for compound containing endoperoxide functional group, additionally by single crystal X-ray diffraction analysis.




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