Chemistry Journal of Moldova

GREEN AND EFFICIENT SYNTHESIS OF DIHYDROPYRIMIDINONE ANALOGUES VIA HPA-CLAY CATALYZED BIGINELLI REACTION

Author(s):

Nuzhat Rehman, Ayaz Mahmood Dar, Raja Feroz Ahmad Haji, Sharief-ud-din Khan, Deepak Pareek, Saleem Farooq, Bashir Ahmad Dar


Field: Organic chemistry
Type: Research paper
Issue: 2024 Volume 19, no.1
Pages: 76-83
Keywords:

multicomponent reaction, heteropolyacid, green chemistry approach, recyclable catalyst.


Full Text (PDF): Download
 
https://doi.org/10.19261/cjm.2024.1135

Abstract (PDF)
Supplementary Material (PDF)
Graphical Abstract: This study presents an eco-friendly method for synthesizing 3,4-dihydropyrimidin-2(1H)-ones (DHPMs) through the Biginelli reaction. A novel Heteropolyacid-Clay (HPA-Clay) catalyst, formed by immobilizing H5PV2W10O40 on Montmorillonite KSF clay, displays enhanced stability and catalytic efficiency. Operating under solvent-free, one-pot conditions, the process delivers DHPMs with high yields and shortened reaction times. Catalyzed by 2 mol% HPA-Clay, it adheres to green chemistry principles, emphasizing cost-efficiency, environmental sustainability, and recyclability. The catalyst consistently performs over multiple cycles, showcasing promise for advancing Biginelli reactions.


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