Graphycal Abstract: The study represents an analysis of the dynamics of self-purification processes in the Dniester River waters over ten years, conducted based on five hydrochemical and kinetic parameters. The study results demonstrated that the Dniester River waters are also loaded with reducing compounds, especially from the Răut and Ichel tributaries, which diminishes the intensity of the self-purification processes. However, after the last sampling point, a slight trend toward restoring initial properties was observed.