Chemistry Journal of Moldova

THE Co-N BOND CLEAVAGE IN THE ADENOSYNCOBALAMIN COFACTOR IN ADVANCE TO GLUTAMATE MUTASE AND METHYLMALONYL-CoA MUTASE PROCESSES

Author(s):

Tudor Spataru


Field: Physical chemistry and chemical physics
Type: Research paper
Pages: 9
Keywords:

glutamate mutase, methylmalonyl-CoA mutase, adenosylcobalamin cofactor, vitamin B12, Pseudo-Jahn-Teller effect.


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http://doi.org/10.19261/cjm.2023.1087

Graphical Abstract: The Pseudo-Jahn-Teller-Effect governs the glutamate mutase and methylmalonate-CoA mutase preliminary step and provides insight into particular details of in vivo C-N bond cleavage reactions of the adenosylcobalamin cofactor. Multi-configurational self-consistent field (MCSCF) calculations show that the preliminary step reaction glutamate mutase and methylmalonate-CoA mutase processes occur in the absence of total energy barriers.





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