Graphical Abstract: With the scope to provide complete decomposition of benzothiazoles in water environment, two approaches have been applied including the photocatalytic and biodegradation processes. A new type of continuous-action flow-through photocatalytic reactor was developed, in which it is possible to combine the homogeneous and heterogeneous destruction of refractory organic pollutants. The interactions between the different components of the aminobenzothiazole-containing system under the conditions of photo- and biodegradation (light, iron, free and immobilized bacterial strain Rhodococcus rhodochrous) were analysed. The combined systems “Fe ± light +Rh.rhodochrous” are more effective than simple systems.